KPV (Lysine-Proline-Valine)
$38.00$24.00
This is a specialized research product of KPV, a tripeptide fragment of alpha-melanocyte-stimulating hormone ($\alpha$-MSH), strictly intended For Research and Laboratory Purposes Only — Not for Human Consumption.
Description & Application
Description: KPV is a tripeptide consisting of the amino acids Lysine, Proline, and Valine. It represents the C-terminal fragment of the $\alpha$-MSH hormone ($\alpha$-MSH 11-13). Despite being a small fragment, it is considered the primary messenger sequence responsible for the hormone's anti-inflammatory properties.
Mechanism: KPV exerts potent anti-inflammatory effects by inactivating inflammatory signaling pathways and inhibiting the synthesis of pro-inflammatory cytokines (such as TNF-$\alpha$). In intestinal cells, its uptake is mediated by the PepT1 transporter.
Research Focus: It is widely utilized in laboratory settings to investigate:
Intestinal Health: Potential in mitigating inflammation associated with bowel dysfunction, ulcerative colitis, and inflammatory bowel disease (IBD).
Dermatological Research: Reducing skin inflammation, dermatitis, and ear swelling in animal models.
Wound Healing & Scarring: Accelerating the healing of cutaneous (skin) and corneal epithelial wounds while potentially reducing scar area.
Antipyretic Action: Research into its ability to modulate body temperature and reduce fever in neurological models.
Immune Modulation: Downregulating the infiltration of inflammatory cells like neutrophils and mast cells.
Specifications & Storage
Unit Size: 4mg (provided as a lyophilized powder).
Purity: >99% (verified via HPLC and Mass Spectrometry).
Molecular Formula: $C_{16}H_{30}N_{4}O_{4}$.
Molecular Weight: 342.43 g/mol.
Other Names: $\alpha$-MSH(11-13), ACTH(11-13).
Storage: Store in a cool, dry place. For long-term preservation of research integrity, refrigeration ($2^{\circ}\text{C}–8^{\circ}\text{C}$) or freezing ($-20^{\circ}\text{C}$) is recommended for the lyophilized powder.
⚠️ Legal & Intended Use
Intended Use: This compound is intended strictly for research and laboratory purposes. It is not approved for human or animal consumption and must not be used in food, drugs, supplements, or cosmetics.
Legal Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Compliance: Core Peptides is a chemical supplier and not a compounding pharmacy. Use is restricted to qualified research professionals in controlled environments.
Safety: Misuse of this product is strictly prohibited.